As a subject matter expert in pharmacokinetics and the endocannabinoid system, I am well-versed in the metabolic processes of various compounds, including cannabidiol, or CBD. CBD is a non-psychoactive component of the cannabis plant that has gained significant attention for its potential therapeutic benefits. Understanding the clearance time of CBD from the body is crucial for individuals who may be subject to drug testing or simply wish to know more about its pharmacokinetics.

The clearance of CBD from the body is influenced by several factors, including dosage, frequency of use, metabolism, body fat, and individual differences in physiology. Generally, CBD is thought to have a half-life of approximately 18 to 32 hours, which means that it takes this amount of time for half of the substance to be eliminated from the body. However, the complete clearance of CBD can take longer, often around 3 to 5 days, as you mentioned. This timeline can vary based on the factors mentioned earlier.

The study you referenced, where patients were administered high doses of 700 mg of CBD per day for an extended period, provides valuable insight into the pharmacokinetics of CBD at higher dosages. In such cases, the accumulation of CBD in the system can lead to a longer detection time. It is important to note that the effects of CBD, such as relaxation and pain relief, typically last for a shorter duration, around 3 to 4 hours, as the body metabolizes and eliminates the compound.

It is also worth mentioning that the method of consumption can impact how long CBD stays in the system. Ingesting CBD orally, for instance, can result in a slower onset but potentially longer-lasting effects compared to inhalation or sublingual administration.

When considering drug testing, it's important to recognize that most standard drug tests screen for THC, the psychoactive component of cannabis, rather than CBD. However, some tests may be sensitive enough to detect CBD metabolites, particularly after high-dose or prolonged use.

In conclusion, while the general consensus is that CBD clears from the system within 3 to 5 days, this can be subject to variation based on individual factors and usage patterns. For those concerned about the detection of CBD, understanding these variables and the specifics of the testing protocol is essential.

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How Long Does CBD Oil Stay In Your System? The answer is CBD stays in your system for about 3-5 days, but the effects will only last about 3-4 hours. In one study, you can find here, The patients were taking extremely high doses of 700 mg of CBD/day for 6 weeks.read more >>