Depakote has a half life of 9 - 16 hours. This means that every 9 to 16 hours, half of the previous amount of Depakote in the body disappears. It usually takes around 5.5 half lives for a drug to get out of your system. As a guide then, after 3 -4 days Depakote should be out of your system.Sep 3, 2017read more >>