As a pharmaceutical expert with a deep understanding of medication dosages and their equivalences, I am well-equipped to address the complex nature of comparing Adderall and Vyvanse dosages. It is important to note that these medications are both used to treat attention deficit hyperactivity disorder (ADHD), but they contain different active ingredients and have different mechanisms of action.

Adderall contains a mixture of amphetamine salts, which includes both dextroamphetamine (right-handed amphetamine) and levoamphetamine (left-handed amphetamine). The term "mg" in the context of Adderall refers to the total milligrams of these amphetamine salts.

Vyvanse, on the other hand, contains lisdexamfetamine, which is a prodrug. This means that it is a precursor to the active drug, in this case, dextroamphetamine. When ingested, Vyvanse is metabolized by red blood cells and converted into dextroamphetamine. The conversion rate mentioned, 0.2948, is a critical piece of information for determining the equivalence between the two drugs.

Given the conversion rate of 0.2948, if we were to calculate the equivalence based on the information provided, 30mg of Vyvanse would be metabolized into approximately 8.85mg of dextroamphetamine. However, since Adderall contains both dextroamphetamine and levoamphetamine, we need to consider the total amphetamine content. The equivalence provided in the reference suggests that 30mg of Vyvanse is equivalent to 11.8mg of Adderall. This is based on the assumption that the conversion of lisdexamfetamine to dextroamphetamine is the primary factor in determining the equivalence.

It's important to recognize that the duration of action for these medications can also vary significantly. Adderall typically lasts for about 4 to 6 hours, while Vyvanse has a longer duration of action, often lasting 10 to 14 hours. This difference in duration can influence the choice of medication for individuals with ADHD, depending on their specific needs and lifestyle.

When comparing the dosages of these medications, it is crucial to consult with a healthcare provider. They can provide personalized advice based on an individual's medical history, current medications, and the severity of their ADHD symptoms. It is not recommended to adjust dosages or switch medications without professional guidance, as this can have serious health implications.

In conclusion, while the conversion rate can provide a starting point for understanding the equivalence between Adderall and Vyvanse, it is just one aspect of a much more complex clinical decision-making process. The ultimate goal is to find the most effective treatment for each individual with ADHD, and this often involves a trial-and-error period to determine the optimal dosage and medication.

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Probably lasts 8-10 hours but can be quite variable. Equal to TDD of Dexadrine IR. A bit tricky: A prodrug that is converted to dextroamphetamine by the hydrolytic activity of red blood cells. The --conversion rate-- is measured at 0.2948, meaning 30mg Vyvanse is equal to 8.85 mg dextroamphetamine, or 11.8 mg Adderall.read more >>