As a medical professional with a focus on pharmacology, I can provide a detailed comparison between aspirin and ibuprofen. Both are nonsteroidal anti-inflammatory drugs (NSAIDs), but they have distinct chemical structures and properties that influence their uses, side effects, and interactions with other medications.

Aspirin is an acetylsalicylic acid that has been in use for over a century. It's well-known for its analgesic (pain-relieving), antipyretic (fever-reducing), and anti-inflammatory effects. Aspirin also has an antiplatelet effect, which means it can help prevent blood clots, making it a common choice for long-term use in people at risk of heart attack or stroke.

Ibuprofen, sold under various brand names including Motrin and Advil, is part of a subclass of NSAIDs known as propionic acid derivatives. It's similar to aspirin in that it also provides pain relief, reduces fever, and has anti-inflammatory properties. However, ibuprofen is not an antiplatelet agent, so it doesn't have the same blood-thinning effects as aspirin.

While both drugs are effective for similar conditions, there are differences in their side effect profiles. Aspirin, particularly in higher doses, can cause more irritation to the gastrointestinal (GI) tract, leading to stomach upset and, in some cases, ulcers. Ibuprofen, in comparison, seems to be less irritating to the esophagus and stomach lining, especially at lower doses.

Another NSAID, Naproxen, sold as Aleve, is also worth mentioning. Naproxen is chemically different from both aspirin and ibuprofen and is particularly noted for its strong anti-inflammatory effects. It's often used for conditions like arthritis, menstrual cramps, and other inflammatory conditions where a more potent anti-inflammatory effect is desired.

Each of these NSAIDs has its own set of indications, contraindications, and side effects that should be considered when choosing between them. For instance, aspirin's antiplatelet effect makes it unsuitable for people with certain bleeding disorders or those taking anticoagulants. Ibuprofen, while less likely to cause GI issues, can still affect kidney function and increase the risk of heart problems in high doses or long-term use, especially in people with pre-existing cardiovascular disease.

In conclusion, while aspirin and ibuprofen share some similarities as NSAIDs, they are not the same thing. Their chemical structures, effects, side effects, and specific uses vary, and a healthcare provider should be consulted to determine the most appropriate medication for an individual's needs.

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Ibuprofen, sold as Motrin or Advil, is chemically similar to regular aspirin and functions in a similar way. In lower doses, ibuprofen seems to irritate the esophagus and stomach lining less than aspirin and naproxen. ... Naproxen, sold as Aleve, is especially effective as an anti-inflammatory agent.May 17, 2011read more >>