As a medical professional with expertise in cardiology, I can explain that nonspecific ST-T wave abnormalities on an electrocardiogram (ECG) refer to changes in the ECG waveform that do not have a clear or specific diagnostic significance. These changes can be seen in a variety of conditions, both cardiac and non-cardiac, which makes them difficult to interpret without additional clinical context. The ST segment represents the period between the end of the ventricular depolarization (contraction) and the beginning of ventricular repolarization (relaxation). The T wave corresponds to the repolarization phase. Abnormalities in these areas can be due to a number of factors, including but not limited to: 1. Intrinsic myocardial disease: Conditions such as myocarditis (inflammation of the heart muscle), ischemia (reduced blood supply to the heart), infarction (heart attack), or other infiltrative or myopathic processes can affect the ST-T wave configuration. 2. Electrolyte imbalances: Abnormal levels of electrolytes like potassium, calcium, or magnesium can alter the ECG. 3. Drug effects: Certain medications can cause changes in the ST-T wave. 4. Non-cardiac conditions: Sometimes, ST-T wave changes can be seen in individuals with no heart disease, particularly in the presence of electrolyte imbalances, metabolic disorders, or other systemic illnesses. When an ECG reveals nonspecific ST-T wave abnormalities, further evaluation is typically required. This may include a detailed patient history, physical examination, laboratory tests, and possibly additional imaging or specialized cardiac tests to determine the underlying cause. read more >>

Thus the term, nonspecific ST-T wave abnormalities, is frequently used when the clinical data are not available to correlate with the ECG findings. ... Factors affecting the ST-T and U wave configuration include: Intrinsic myocardial disease (e.g., myocarditis, ischemia, infarction, infiltrative or myopathic processes)read more >>