As a domain expert in pharmacology, I can provide you with information on the signs and symptoms of digoxin toxicity. Digoxin is a medication that is used to treat heart conditions such as atrial fibrillation and heart failure. However, it has a narrow therapeutic index, which means that the difference between a safe dose and a toxic dose is small. When a patient experiences digoxin toxicity, it can manifest in various ways, including gastrointestinal (GI) symptoms, cardiac symptoms, and neurological symptoms.
GI symptoms in acute or chronic toxicity include:
-
Anorexia
- Weight loss
- Failure to thrive (in pediatric patients)
-
Nausea
-
Vomiting
- Abdominal pain
- Diarrhea
- Mesenteric ischemia (a rare complication of rapid IV infusion)
Cardiac symptoms may include:
- Arrhythmias, such as ventricular tachycardia or atrial fibrillation with rapid ventricular response
- Bradycardia
- Weakness or fatigue
Neurological symptoms can involve:
- Visual disturbances, such as blurred vision or yellow-green halos around objects (xanthopsia)
- Confusion
- Drowsiness
- Headache
- Seizures
It's important to note that the severity and combination of symptoms can vary widely among individuals. If digoxin toxicity is suspected, immediate medical attention is necessary to manage the condition and prevent serious complications.
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