As a clinical pharmacist with expertise in pharmacotherapy, I can provide you with information on the reversal of heparin's effects. When it is necessary to reverse the anticoagulant effects of heparin due to bleeding or other clinical reasons, protamine sulfate is the agent of choice. It is administered as a slow infusion, typically using a 1% solution. The administration of protamine sulfate should be done cautiously, with no more than 50 mg given over any 10-minute period to avoid potential adverse effects. The neutralization ratio is approximately 1 mg of protamine sulfate for every 100 units of heparin. It is important to closely monitor the patient's coagulation status and adjust the dose of protamine sulfate accordingly. read more >>

When clinical circumstances (bleeding) require reversal of heparinization, protamine sulfate (1% solution) by slow infusion will neutralize heparin sodium. No more than 50 mg should be administered, very slowly in any 10 minute period. Each mg of protamine sulfate neutralizes approximately 100 USP heparin units.read more >>