As a domain expert in neuroscience and physiology, I can provide a detailed explanation of depolarization. Definition of depolarization: Depolarization refers to the process in which the resting membrane potential of a cell, particularly a neuron or muscle cell, becomes less negative or more positive. This occurs when there is a decrease in the difference in electrical charge across the cell membrane. It is often initiated by an influx of positively charged ions, such as sodium (Na+), which enter the cell through voltage-gated ion channels. This influx of ions causes the inside of the cell to become less negative (less polarized) relative to the outside, and it is a critical step in the generation of an action potential, which is the electrical signal that neurons and muscle cells use to communicate. read more >>

medical Definition of depolarization. : loss of polarization; especially : loss of the difference in charge between the inside and outside of the plasma membrane of a muscle or nerve cell due to a change in permeability and migration of sodium ions to the interior.read more >>