As a neuroscientist with a focus on cellular and molecular neuroscience, I can explain the concept of the threshold of excitation in neurons.
The
threshold of excitation, also simply referred to as the
threshold, is a critical value that a neuron's membrane potential must reach in order to trigger an action potential. This is a fundamental concept in understanding how neurons communicate with each other through electrical signals.
In most neurons, the threshold is typically around
-55mV to -65mV. When the membrane potential of a neuron reaches this level, it indicates that the cell has reached a state of sufficient depolarization to initiate an action potential. An action potential is characterized by a rapid depolarization, during which the membrane potential becomes less negative (or more positive), followed by a slight reversal of the usual membrane polarization. This process involves the opening and closing of ion channels, which allows for the flow of ions like sodium (Na+) and potassium (K+) across the neuron's cell membrane.
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