As a domain expert in pharmacology, I can provide you with information on local anesthetics and their potential to cause methemoglobinemia. Methemoglobinemia is a condition where a certain percentage of hemoglobin in the blood is converted to methemoglobin, which is unable to carry oxygen effectively.

Among the local anesthetics, the one most commonly associated with the risk of methemoglobinemia is Prilocaine. Prilocaine is a local anesthetic that has been used for various procedures due to its fast onset and relatively short duration of action. However, it has a higher propensity to cause methemoglobinemia compared to other local anesthetics, particularly when used in high doses or in patients with certain genetic predispositions.

It's important to note that while prilocaine is the most commonly implicated, other local anesthetics can also cause methemoglobinemia, but to a lesser extent. This includes benzocaine and lidocaine, although the risk is much lower.

In clinical practice, if a patient is at risk for developing methemoglobinemia, healthcare providers may opt for alternative local anesthetics or closely monitor patients for signs of methemoglobin formation.

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Drugs causing MetHb: local anesthetics: prilocaine (with lidocaine in EMLA cream. Large amount �C 600 mg doses required for development of MetHb; prilocaine generates O-toluidine which oxidizes Hb) lidocaine.read more >>