Cancer in the bone can be particularly painful for several reasons. Firstly, cancer cells can produce substances that dissolve and weaken the bones, which can lead to a bone fracture. The process of a bone breaking is naturally associated with significant pain. Secondly, as the tumor grows within the bone, it can compress or irritate the nerve endings that are in close proximity to the bone. This can result in persistent and severe pain as these nerves send distress signals to the brain. Additionally, in some cases, cancer cells might cause the bones to harden, a process that can also lead to discomfort and pain due to the increased pressure on the bone and surrounding tissues. read more >>

They produce substances that can dissolve and weaken bones. This may cause a bone to break, which is painful. As the tumor grows in the bone, nerve endings in and around the bone also send pain signals to the brain. They may make bones harden.read more >>