Hello, I'm an expert in comic book lore, particularly the Marvel Universe. When it comes to Iron Man's greatest enemy, there are several contenders, but the most iconic and persistent foe is
Mandarin.
Mandarin is a genius inventor and strategist with access to the Ten Rings, which are not only powerful weapons but also grant him various abilities. He's one of the founding members of the comic book villain team, the Masters of Evil. Mandarin has been a thorn in Iron Man's side since his first appearance in "Tales of Suspense" #50 in 1964.
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