As a subject matter expert in comic book lore and superhero narratives, I can provide you with an accurate answer regarding Jessica Jones' primary antagonist.

Jessica Jones, a character from the Marvel Comics universe, has faced numerous adversaries throughout her comic and television appearances. However, her most notable and recurring enemy is Kilgrave, also known as the Mind-Controlling Villain. Kilgrave possesses the power of mind control, which he uses to manipulate those around him, including Jessica Jones, for his own nefarious purposes. Their conflict is particularly personal as Kilgrave's control over Jessica led to a period of trauma and abuse that significantly impacted her life and career as a private investigator.

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Created by writer Stan Lee and artist Joe Orlando, he first appeared in Daredevil #4 (October 1964). His body produces pheromones which allow him to verbally control the actions of others. Initially a recurring enemy of Daredevil, in the 2000s he emerged as the archenemy of Jessica Jones and her husband Luke Cage.read more >>