As a medical professional with expertise in autoimmune disorders, I can provide you with a comprehensive overview of the severe symptoms associated with lupus, a chronic inflammatory disease that can affect various parts of the body. Lupus, also known as systemic lupus erythematosus (SLE), is characterized by periods of illness (flares) and remission. It's important to recognize the signs of severe lupus to seek prompt medical attention and manage the condition effectively. Severe symptoms of lupus can be diverse and include, but are not limited to, the following: 1. Achy Joints (Arthralgia): Persistent pain in the joints without redness or warmth, which can be a sign of lupus. 2. Unexplained Fever: A fever that is unaccompanied by an infection or other identifiable cause, often above 100 F (37.8 C), can be a sign of a lupus flare. 3. Swollen Joints (Arthritis): Inflammation in one or more joints, leading to swelling, stiffness, and pain that can be severe and debilitating. 4. Prolonged or Extreme Fatigue: A deep, unrelenting tiredness that is not relieved by rest and can significantly impact daily activities. 5. Skin Rash: A lupus rash can occur when the skin is exposed to sunlight. The most common type is a butterfly rash, which appears across the cheeks and nose in a butterfly shape. 6. Ankle Swelling and Fluid Accumulation: Swelling due to the accumulation of fluid, which can be a sign of nephrotic syndrome, a severe complication of lupus that affects the kidneys. 7. **Pain in the Chest When Breathing Deeply (Pleurisy)**: Sharp chest pain that worsens with a deep breath, indicating inflammation of the lining around the lungs. 8. **Butterfly-Shaped Rash Across the Cheeks and Nose**: A distinctive rash over the cheeks and bridge of the nose, which is often a hallmark of lupus. 9. Kidney Involvement (Nephritis): Inflammation of the kidneys can lead to protein in the urine, high blood pressure, and potentially kidney failure. 10. Neurological Symptoms: Lupus can cause a range of neurological problems, including headaches, seizures, and cognitive dysfunction. 11. Blood Disorders: Anemia, leukopenia (low white blood cell count), and thrombocytopenia (low platelet count) can occur due to the body attacking its own blood cells. 12. Raynaud's Phenomenon: Cold, blue fingers and toes due to reduced blood flow, which can be triggered by cold temperatures or stress. 13. Serositis: Inflammation of the lining of the body cavities, such as the pleura (around the lungs) and the pericardium (around the heart). 14. Vasculitis: Inflammation of blood vessels, which can lead to tissue damage and organ dysfunction. 15. Foamy Urine (Proteinuria): Excessive protein in the urine, which can be a sign of kidney involvement. 16. Mouth and Nose Sores: Ulcers in the mouth and nose can be painful and are indicative of lupus activity. 17. Hair Loss (Alopecia): Patchy or total hair loss can occur due to inflammation affecting the hair follicles. 18. Photosensitivity: Skin that becomes more sensitive to sunlight, causing rashes or worsening of existing rashes. 19. Fever and Chills: Unexplained fever and chills can be indicative of a lupus flare. 20. Weight Loss: Unintentional weight loss without any dietary changes can be a sign of a severe lupus flare. Recognizing these severe symptoms is crucial for individuals with lupus. It's important to consult with a healthcare provider for a proper diagnosis and treatment plan. Early intervention can help manage the disease and prevent complications. read more >>

What Are the Symptoms of Lupus?Achy joints (arthralgia)Unexplained fever (more than 100 F)Swollen joints (arthritis)Prolonged or extreme fatigue.Skin rash.Ankle swelling and fluid accumulation.Pain in the chest when breathing deeply (pleurisy)A butterfly-shaped rash across the cheeks and nose.More items...read more >>