As a neuroscientist with a focus on cellular and molecular neuroscience, I can tell you that the action potential is a critical mechanism for the propagation of signals in neurons. It's initiated when a stimulus alters the membrane potential of a cell to a level that triggers a rapid, self-propagating depolarization.
The
threshold for an action potential is typically reached when the membrane potential of a neuron reaches a level slightly more negative than the resting potential, which is around
-55 mV. This value can vary slightly depending on the neuron type and the species. Once this threshold is crossed, voltage-gated sodium channels open, leading to a rapid influx of sodium ions, which causes the membrane potential to become positive and initiates the action potential.
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