Mannitol decreases blood viscosity, CBF unchanged while CBV and
ICP decrease.
Mannitol also
reduces ICP by
reducing cerebral parenchymal cell water, total effect takes 20-30min. Eventually
Mannitol enters CSF and increases
ICP. 3% Saline has similar osmotic effect as
Mannitol. ... NMB
reduces ICP by avoiding coughing.
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