Hello, I'm a healthcare professional with a background in pharmacology. When it comes to antidepressants and their potential for causing weight gain, it's important to note that individual responses can vary greatly. However, some antidepressants are less likely to contribute to weight gain compared to others. Here's a brief overview:


1. Bupropion (Wellbutrin) - This medication is sometimes prescribed as a smoking cessation aid and is known for its minimal impact on weight.

2. Venlafaxine (Effexor) - At lower doses, this medication may not cause significant weight gain, but higher doses can have the opposite effect.

3. Agomelatine - This is a newer type of antidepressant that has shown less association with weight gain in clinical trials.

4. Reboxetine - A selective norepinephrine reuptake inhibitor (NRI), which may have a lower risk of weight gain.

It's crucial to discuss with a healthcare provider before starting any medication, as they can provide personalized advice based on medical history and specific conditions.

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Conversely, he says that one of the antidepressants that seems most likely to cause weight gain is Paxil, an SSRI (selective serotonin reuptake inhibitor). Of the other SSRIs, which include Prozac, Lexapro and Celexa, Zoloft may be least likely to cause weight gain. No one knows for sure why antidepressants do this.read more >>