As a medical professional with expertise in pharmacology, I can provide you with information on drugs that are known to prolong the QT interval, which is a measure of the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle as measured on an electrocardiogram (ECG). Prolongation of the QT interval can lead to a serious heart rhythm disturbance known as torsades de pointes, which can be life-threatening.

**Drugs that are known to prolong the QT interval include:**


1. Antiarrhythmic medications (Class IA and III)

2. Antibiotics such as macrolides (e.g., erythromycin, azithromycin), fluoroquinolones (e.g., moxifloxacin, levofloxacin), and pentamidine

3. Antidepressants and antipsychotics (e.g., certain phenothiazines, tricyclic antidepressants like amitriptyline, and some atypical antipsychotics)

4. Antimalarial drugs like halofantrine and mefloquine

5. Gastrointestinal medications such as cisapride (which has been withdrawn in many countries due to safety concerns)

6. Cardiovascular drugs including some antihypertensives (e.g., sotalol, amiodarone)
7.
Dronedarone, used for atrial fibrillation

It's important to note that the risk of QT prolongation can be influenced by factors such as dosage, co-administration with other QT-prolonging drugs, underlying heart conditions, and individual genetic predispositions.

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Drugs Causing QT ProlongationAntipsychoticsType IA antiarrhythmicsType IC antiarrhythmicsChlorpromazine Haloperidol Droperidol Quetiapine Olanzapine Amisulpride ThioridazineQuinidine Procainamide DisopyramideFlecainide Encainideread more >>