As a medical expert, I can tell you that the end stage of kidney failure, also known as end-stage renal disease (ESRD), represents the most severe phase of chronic kidney disease. When kidneys fail, it means they are no longer able to function at a level that sustains life without the assistance of dialysis or a kidney transplant. At this point, the kidneys can't adequately filter waste products from the blood, leading to a toxic buildup of these substances in the body. This can cause a range of symptoms and complications, including水肿 (swelling), 高血压 (high blood pressure), 疲劳 (fatigue), and 更严重的症状 (more severe symptoms) that can affect various systems within the body.
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