As a domain expert in cardiology, I can tell you that the main cause of ischemic heart disease is the narrowing of the coronary arteries, which supply blood and oxygen to the heart muscle. This narrowing is often due to the buildup of plaque, which is made up of fat, cholesterol, and other substances in the blood. When these substances accumulate, they form a hard, crusty deposit inside the arteries, a condition known as atherosclerosis. This process restricts blood flow, leading to ischemia, which means the heart muscle doesn't get enough blood and oxygen to work properly. The reduced blood supply can cause angina pectoris, which is chest pain or discomfort. If the blood supply is severely blocked, it can result in a heart attack. read more >>

When arteries are narrowed, less blood and oxygen reaches the heart muscle. This is also called coronary artery disease and coronary heart disease. This can ultimately lead to heart attack. Ischemia often causes chest pain or discomfort known as angina pectoris.read more >>