As a subject matter expert in pharmacology, I can provide you with information on the half-life of amiodarone. Amiodarone is a medication used to treat various types of arrhythmias, which are irregular heartbeats. The half-life of a drug is the time it takes for the concentration of the drug in the body to decrease by half. For amiodarone, the half-life is quite long, typically ranging from 26 to 107 days, with an average of about 50 days. This long half-life is due to the high lipid solubility of the drug, which allows it to be stored in fatty tissues and released slowly over time. It's important to note that the duration of therapeutic effects and the time to reach steady-state concentrations can be quite prolonged due to this extended half-life. read more >>

Following single dose administration in 12 healthy subjects, Amiodarone exhibited multi-compartmental pharmacokinetics with a mean apparent plasma terminal elimination half-life of 58 days (range 15 to 142 days) for Amiodarone and 36 days (range 14 to 75 days) for the active metabolite (DEA).read more >>