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Why does it take more anesthesia for redheads?
Genetic Factors Body Composition Age
Questioner：Julian Thompson 2023-04-06 14:05:11
The most authoritative answer in 2024
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Owen Gonzales——Works at the International Atomic Energy Agency, Lives in Vienna, Austria.
As a medical professional with expertise in anesthesia, I can provide some insights into the factors that may influence the amount of anesthesia required for patients. However, it's important to note that the idea that redheads require more anesthesia is a common myth and not supported by scientific evidence.
Anesthetic requirements can vary significantly among individuals due to a number of factors, including:
1. Genetic Factors: Some studies suggest that certain genetic variations can influence how an individual metabolizes anesthetic drugs. For example, variations in the gene CYP2D6 can affect the metabolism of many medications, including some anesthetics.
2. Body Composition: An individual's weight and body fat percentage can affect the distribution and elimination of anesthetic drugs.
3. Age: Both younger and older patients may require different doses of anesthesia due to differences in how their bodies process drugs.
4. Health Status: Patients with certain health conditions or those taking other medications can have altered responses to anesthesia.
5. Surgical Procedure: The type of surgery and the patient's response to it can also influence the amount of anesthesia needed.
The myth about redheads requiring more anesthesia likely stems from the fact that redheads have a genetic mutation in the MC1R gene, which is associated with higher pain tolerance. However, this does not directly translate to a requirement for more anesthesia. Pain tolerance and anesthetic requirements are complex and influenced by many factors, not just a single gene.
In conclusion, while there are genetic and other factors that can influence anesthetic requirements, the idea that redheads universally need more anesthesia is not scientifically accurate.
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Sophia Wright——Studied at University of Oxford, Lives in Oxford, UK
4. Need more anesthesia during surgery. Redheads need 20 percent more anesthesia than their dark-headed counterparts. Because the MC1R gene belongs to the same family of genes that play a role in pain, the mutation causes redheads to be more sensitive to it.read more >>+119962023-04-16 14:05:11
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