As a medical professional with expertise in pharmacology, I can provide you with information on anti-inflammatory medications. It's important to note that the concept of the "safest" medication is relative and depends on the individual's health condition, the specific inflammation being treated, and the potential side effects of the medication.

For mild inflammation, over-the-counter (OTC) nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen are often considered safe when used as directed. However, these can cause gastrointestinal issues, especially in people with a history of ulcers or gastrointestinal bleeding.

For those with a higher risk of gastrointestinal side effects, celecoxib (a COX-2 inhibitor) may be a safer alternative as it has fewer gastrointestinal side effects compared to traditional NSAIDs. However, it can still cause cardiovascular and renal side effects in some individuals.

In cases where NSAIDs are not suitable, topical NSAIDs can be a safer option as they are applied directly to the area of inflammation, reducing the risk of systemic side effects.

It's crucial to consult with a healthcare provider before starting any medication to ensure it's the safest choice for your specific needs. A healthcare professional can assess your medical history, current medications, and overall health to determine the safest and most effective treatment.

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Natural and Safe Anti-Inflammatory Medicines. ... And that adds up to a lot of drug use, notably the category called NSAID's, or non-steroidal anti-inflammatory drugs. Ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren) and Celebrex belong to this class of drugs.read more >>