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In the "Amazing Spider-Man" comic series, Uncle Ben's death is a pivotal moment that shapes Peter Parker's life and his commitment to fighting crime as Spider-Man.
Uncle Ben was killed by a burglar who had earlier escaped from a confrontation with Peter. The young Parker had the opportunity to stop the thief but chose not to get involved, believing it was not his responsibility. This decision haunts him when the same burglar later murders his beloved Uncle Ben. This tragedy instills in Peter the realization that with great power comes great responsibility, a lesson that becomes the guiding principle for his superhero career.

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Neither in the comics, nor in the Sam Raimi movie does Spider-Man kill the person responsible for Uncle Ben's death (in the comics he dies of a heart attack, in the movie he falls out of a window. Although Spider-Man 3 reveals that it was actually Flint Marko who shot Uncle Ben).read more >>